1. Giorgino R, Albano D, Fusco S, Peretti GM, Mangiavini L, Messina C. Knee osteoarthritis: epidemiology, pathogenesis, and mesenchymal stem cells: what else is new? An update. International Journal of Molecular Sciences 2023; 24(7): 6405. ## [DOI:10.3390/ijms24076405] [PMID] []

2. Liang J, Wang Y, Yu F, Jiang G, Zhang W, Tian K. Evaluation of the osteoarthritis disease burden in China from 1990 to 2021: based on the Global Burden of Disease Study 2021. Frontiers in Public Health 2024; 12: 1478710. ## [DOI:10.3389/fpubh.2024.1478710] [PMID] []

3. Semenistaja S, Skuja S, Kadisa A, Groma V. Healthy and osteoarthritis-affected joints facing the cellular crosstalk. International Journal of Molecular Sciences 2023; 24(4): 4120. ## [DOI:10.3390/ijms24044120] [PMID] []

4. Liu L, Luo P, Yang M, Wang J, Hou W, Xu P. The role of oxidative stress in the development of knee osteoarthritis: A comprehensive research review. Frontiers in Molecular Biosciences 2022; 9: 1001212. ## [DOI:10.3389/fmolb.2022.1001212] [PMID] []

5. Xiao Z, Yu X, Zhang S, Liang A. The expression '2levels and significance of GSH, MDA, SOD, and 8‐OHdG in osteochondral defects of rabbit knee joints. BioMed Research International 2022; 2022(1): 6916179. ## [DOI:10.1155/2022/6916179] [PMID] []

6. Mohideen K, Sudhakar U, Balakrishnan T, Almasri MA, Al-Ahmari MM, Al Dira HS, Suhluli M, Dubey A, Mujoo S, Khurshid Z, Raj AT. Malondialdehyde, an oxidative stress marker in oral squamous cell carcinoma-A systematic review and meta-analysis. Current Issues in Molecular Biology 2021; 43(2): 1019-35. ## [DOI:10.3390/cimb43020072] [PMID] []

7. Di Meo S, Venditti P. Evolution of the knowledge of free radicals and other oxidants. Oxidative Medicine and Cellular Longevity 2020; 2020(1): 9829176. ## [DOI:10.1155/2020/9829176] [PMID] []

8. Kennedy L, Sandhu JK, Harper ME, Cuperlovic-Culf M. Role of glutathione in cancer: from mechanisms to therapies. Biomolecules 2020; 10(10): 1429. ## [DOI:10.3390/biom10101429] [PMID] []

9. Parcheta M, Świsłocka R, Orzechowska S, Akimowicz M, Choińska R, Lewandowski W. Recent developments in effective antioxidants: The structure and antioxidant properties. Materials 2021; 14(8): 1984. ## [DOI:10.3390/ma14081984] [PMID] []

10. Stephenie S, Chang YP, Gnanasekaran A, Esa NM, Gnanaraj C. An insight on superoxide dismutase (SOD) from plants for mammalian health enhancement. Journal of Functional Foods 2020; 68: 103917. ## [DOI:10.1016/j.jff.2020.103917]

11. Islam MN, Rauf A, Fahad FI, Emran TB, Mitra S, Olatunde A, et al. Superoxide dismutase: an updated review on its health benefits and industrial applications. Critical Reviews in Food Science and Nutrition 2022; 62(26): 7282-300. ## [DOI:10.1080/10408398.2021.1913400] [PMID]

12. Frye KA, Sendra KM, Waldron KJ, Kehl-Fie TE. Old dogs, new tricks: New insights into the iron/manganese superoxide dismutase family. Journal of Inorganic Biochemistry 2022; 230: 111748. ## [DOI:10.1016/j.jinorgbio.2022.111748] [PMID] []

13. Orfanakos K, Alifieris CE, Verigos EK, Deligiorgi MV, Verigos KE, Panayiotidis MI, et al. The predictive value of 8-hydroxy-deoxyguanosine (8-OHdG) serum concentrations in irradiated non-small cell lung carcinoma (NSCLC) patients. Biomedicines 2024; 12(1): 134. ## [DOI:10.3390/biomedicines12010134] [PMID] []

14. Boukhris M, Simmonds MS, Sayadi S, Bouaziz M. Chemical composition and biological activities of polar extracts and essential oil of rose‐scented geranium, Pelargonium graveolens. Phytotherapy Research 2013; 27(8): 1206-13. ## [DOI:10.1002/ptr.4853] [PMID]

15. Lavasanijou MR, Sohrabi HR, Karimi M, Ashjazade MA, Salajeghe M, Farzineejadizadeh H, Parsaei P, Elmamooz A. Wound healing effects of quercus brantii and Pelargonium graveolens extracts in male wistar rats. Wounds 2016; 28(10): 369-75. ##

16. Verma RK, Yadav A, Verma RS, Rahman LU, Khan K. Intercropping of aromatic crop Pelargonium graveolens with Solanum tuberosum for better productivity and soil health. Journal of Environmental Biology 2014; 35(6): 1165. ##

17. Gong X, Ivanov VN, Hei TK. 2, 3, 5, 6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells. Archives of Toxicology 2016; 90: 2187-200. ## [DOI:10.1007/s00204-015-1600-z] [PMID] []

18. Kikuchi T, Sakuta T, Yamaguchi T. Intra-articular injection of collagenase induces experimental osteoarthritis in mature rabbits. Osteoarthritis Cartilage 1998; 6: 177-86. ## [DOI:10.1053/joca.1998.0110] [PMID]

19. Jiang D, Zou J, Huang L, Shi Q, Zhu X, Wang G, Yang H. Efficacy of intra-articular injection of celecoxib in a rabbit model of osteoarthritis. International Journal of Molecular Sciences 2010; 11(10): 4106-13. ## [DOI:10.3390/ijms11104106] [PMID] []

20. Oukhatem MN, Kameli A, Ferhat MA, Saidi F, Mekarnia M. Rose geranium essential oil as a source of new and safe anti-inflammatory drugs. Libyan Journal of Medicine 2013; 8(1): 22520. ## [DOI:10.3402/ljm.v8i0.22520] [PMID] []

21. Ahmadi-Noorbakhsh S, Mirabzadeh Ardakani E, Sadighi J, Aldavood SJ, Farajli Abbasi M, Farzad-Mohajeri S, et al. Guideline for the care and use of laboratory animals in Iran. Lab Animal 2021; 50(11): 303-5. ## [DOI:10.1038/s41684-021-00871-3] [PMID]

22. Schlosser KK, editor. The Herb Society of America's Essential Guide to Growing and Cooking with Herbs. LSU Press; 2007##

23. Lalli JY, Van Zyl RL, Van Vuuren SF, Viljoen AM. In vitro biological activities of South African Pelargonium (Geraniaceae) species. South African Journal of Botany 2008; 74(1): 153-7. ## [DOI:10.1016/j.sajb.2007.08.011]

24. Khalifeh MS, Hananeh W, Al-Rukibat R, Okour O, Boumezrag A. Clinical and histopathological evaluation of MDP/collagen induced arthritis rat model (MCIA) after treatment with Urtica dioica, Plantago major and Hypericum perforatum L herbal mixture. Experimental Animals 2008; 57(2): 101-10. ## [DOI:10.1538/expanim.57.101] [PMID]

25. Mehling R, Schwenck J, Lemberg C, Trautwein C, Zizmare L, Kramer D, et al. Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions. Theranostics 2021; 11(2): 470. ## [DOI:10.7150/thno.51462] [PMID] []

26. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry 1979; 95(2): 351-8. ## [DOI:10.1016/0003-2697(79)90738-3] [PMID]

27. Kumar M, Jeevitha M, Jayaraman S. Assessment of 8-Hydroxy 2-Deoxyguanosine as Salivary Biomarker for Periodontitis Patients with or without Diabetes Mellitus. Journal of Pharmaceutical Research International 2021; 33(62B): 8-15. ## [DOI:10.9734/jpri/2021/v33i62B35164]

28. Liu L, Luo P, Yang M, Wang J, Hou W, Xu P. The role of oxidative stress in the development of knee osteoarthritis: A comprehensive research review. Frontiers in Molecular Biosciences 2022; 9: 1001212. ## [DOI:10.3389/fmolb.2022.1001212] [PMID] []

29. Alshehri B. The geranium genus: A comprehensive study on ethnomedicinal uses, phytochemical compounds, and pharmacological importance. Saudi Journal of Biological Sciences 2024; 31(4): 103940. ## [DOI:10.1016/j.sjbs.2024.103940] [PMID] []

30. Pooja G, Shweta S, Patel P. Oxidative stress and free radicals in disease pathogenesis: a review. Discover Medicine 2025; 2(1): 104. ## [DOI:10.1007/s44337-025-00303-y]

31. He F, Wu H, He B, Han Z, Chen J, Huang L. Antioxidant hydrogels for the treatment of osteoarthritis: mechanisms and recent advances. Frontiers in Pharmacology 2024; 15: 1488036. ## [DOI:10.3389/fphar.2024.1488036] [PMID] []

32. Abdulkarim AM, Jassim MM, Hassan ZL. Biomarkers of oxidative stress in rheumatoid arthritis: clinical relevance and therapeutic targets. ##

33. Kim H, Li S, Nilkhet S, Baek SJ. Anti-cancer activity of rose-geranium essential oil and its bioactive compound geraniol in colorectal cancer cells. Applied Biological Chemistry 2025; 68(1): 1-3. ## [DOI:10.1186/s13765-025-01005-w]