Background and purpose: One of the complications of rheumatoid arthritis (RA) is kidney disease. Therefore, the present study investigated the effect of TRX exercises with the addition of avodin on biochemical factors and renal function in patients with RA. Method: 40 people with RA were divided into four groups (N=10): 1) exercise, 2) supplement, 3) exercise+supplement, 4) control. At first, blood was taken from all the subjects to measure the serum level of creatinine (Cr), urea (Urea), urea nitrogen (BUN) and glomerular filtration rate (eGFR). Then TRX exercises and Avodin supplementation (3 sessions per week, 8 weeks, 300 mg/kg body weight) were performed. 2x4 ANOVA test was used to determine the difference between groups, and Bonferroni's post hoc test was used to determine pairwise differences between groups. Also, to check the pre-post-test differences in each group, paired t-test was used. All statistical analyzes were performed by SPSS 27 and the significance level was considered P<0.05. Findings: Significant weight loss in the exercise-supplement group compared to the control group (P=0.037) and the supplement group (P=0.021) and a significant increase in urea, creatinine, BUN and eGFR in the supplement group. compared to other groups (P<0.05) was observed. Also, after examining the pre-post-test and their effect size, it was observed that exercise+supplement had a significant decrease in all variables and had the greatest decreasing effect on them. Conclusion: TRX can reduce the side effects of this supplement and complement the positive effects of the supplement.