The Effect of TRX Training with Avodin Supplement on Biochemical Factors and Renal Function in Patients with Rheumatoid Arthritis

Eskandari,  SH; Sheikhani Shahin , H; Moghadasi , M

doi:10.61186/armaghanj.30.1.33

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Volume 30, Issue 1 (1-2025)

__Armaghane Danesh__ 2025, 30(1): 33-49

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The Effect of TRX Training with Avodin Supplement on Biochemical Factors and Renal Function in Patients with Rheumatoid Arthritis

SH Eskandari¹

, H Sheikhani Shahin²

, M Moghadasi³

1- Department of Exercise Physiology, Shiraz Zand Institute of Higher Education, Shiraz, Iran
2- Department of Exercise Physiology, Shiraz Zand Institute of Higher Education, Shiraz, Iran , hsheikhani@yahoo.com
3- Department of Physical Education and Sport Sciences, Islamic Azad University, Shiraz Branch, Shiraz, Iran

Abstract: (641 Views)

Background & aim: One of the complications of rheumatoid arthritis (RA) is kidney disease. People with rheumatism develop kidney failure, either as a result of the rheumatic disease itself or as a result of taking related medications. Therefore, the present study investigated the effect of TRX exercises with the addition of avodin on biochemical factors and renal function in patients with RA.

Methods: In the present quasi-experimental study conducted in 2022, forty participants with RA were divided into four groups (N=10): 1) exercise, 2) supplement, 3) exercise with supplement, 4) control. At first, blood was taken from all the subjects to measure the serum level of creatinine (Cr), urea (Urea), urea nitrogen (BUN) and glomerular filtration rate (eGFR). Then TRX exercises and Avodin supplementation (3 sessions per week, 8 weeks, 300 mg/kg body weight) were performed. 2x4 ANOVA test was used to determine the difference between groups, and Bonferroni's post hoc test was used to determine pairwise differences between groups. Moreover, to check the pre-post-test differences in each group, paired t-test was used. All statistical analyzes were performed by SPSS 27 and the significance level was considered P<0.05.

Results: Significant weight loss in the exercise-supplement group compared to the control group (P=0.037) and the supplement group (P=0.021) and a significant increase in urea, creatinine, BUN and eGFR in the supplement group. compared to other groups (P<0.05) was observed. Moreover, after examining the pre-post-test and their effect size, it was observed that exercise+supplement had a significant decrease in all variables and had the greatest decreasing effect on them.

Conclusion: TRX can reduce the side effects of this supplement and, on the other hand, enhance the positive effects of the supplement. Therefore, it is recommended that health professionals recommend TRX training and avodin supplementation simultaneously to female patients with RA to achieve greater therapeutic effects and fewer side effects.

Keywords: Rheumatoid Arthritis, Avodin, TRX, Women, Kidney Disease

Full-Text [PDF 716 kb] (57 Downloads)

Type of Study: Research | Subject: Sport Physiology
Received: 2024/09/1 | Accepted: 2025/04/20 | Published: 2025/05/6

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Eskandari S, Sheikhani Shahin H, Moghadasi M. The Effect of TRX Training with Avodin Supplement on Biochemical Factors and Renal Function in Patients with Rheumatoid Arthritis. armaghanj 2025; 30 (1) :33-49
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