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:: Volume 29, Issue 3 (4-2024) ::
__Armaghane Danesh__ 2024, 29(3): 456-466 Back to browse issues page
Restless Legs Syndrome and Quality of Sleep in Pre-diabetic Patients: A Cross Sectional Study
S Razmeh1 , F Sattar2 , SM Ahmadi3 , A Movahedpour4 , L Taghavian5 , F Ganjian1
1- Department of Neurology, Yasuj University of Medical Sciences, Yasuj, Iran
2- Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran, , ftmsattar8415@gmail.com
3- Department of Internal Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
4- Department of Medical Biotechnology, Behbahan Faculty of Medical Sciences, Behbahan, Iran
5- Department of Nursing, Shahid Jalil Hospital, Yasuj University of Medical Sciences, Yasuj, Iran
Abstract:   (1536 Views)
Background & aim: Restless legs syndrome (RLS) is characterized by an uncomfortable urge to move the legs while at rest, relief upon movement or getting up to walk, and worsened symptom severity at night. Studies show that diabetic patients are at high risk of developing RLS and Studies have indicated a high risk of RLS development in diabetic patients, with an established association between RLS and diabetes. RLS has not been investigated in prediabetic patients; Therefore, the aim of the present study was to investigate RLS in prediabetic patients and its relationship with sleep quality, to help improvement of the patient's symptoms and blood sugar control by identifying sleep disorders related to RLS and managing it.


Methods: The present cross-sectional study was conducted on 166 patients meeting inclusion criteria in Yasuj, Iran in 2023. Participants completed the International Restless Legs Syndrome (IRLS) and Pittsburgh Sleep Quality Index (PSQI) questionnaires administered by the researcher. Data analysis was performed using descriptive and analytical statistics through the SPSS software


Results: The mean age of the patients in the present study was 46.23 ± 11.68 years and ranged from 21 to 75 years. 96 (57.8%) were women and 70 (42.2%) were men. The average of RLS score in the examined patients was 6.54 ± 3.05 and ranged from 0 to 35. It was also shown that 68.07% had no symptoms of RLS. Therefore, the prevalence of RLS in pre-diabetic patients was 31.93%. Gender did not significantly affect RLS scores (P=0.951) and there was no significant difference in the severity of RLS between men and women (P=0.097). The mean of the sleep quality score in the investigated patients was 6.25 ± 4.00 and ranged from 0 to 17. It was also shown that 41% had sleep disorders and there was no significant difference between score of sleep quality in men and women (P=0.168). There was no significant difference between men and women having or not having sleep disorders (P=0.240). The results showed that there was a significant and positive relationship between the severity of RLS and sleep disorder. (P

Conclusion: The results of the study indicated a direct and significant relationship between RLS and sleep quality disorders in prediabetic patients.
Keywords: restless legs syndrome, sleep disorder, prediabetes
Full-Text [PDF 501 kb]   (234 Downloads)    
Type of Study: Applicable | Subject: Internist
Received: 2023/12/27 | Accepted: 2024/04/30 | Published: 2024/05/20
References
1. Gossard TR, Trotti LM, Videnovic A, St Louis EK. Restless Legs Syndrome: Contemporary Diagnosis and Treatment. Neurotherapeutics 2021; 18(1): 140-55.## [DOI:10.1007/s13311-021-01019-4] [PMID] []
2. Ulfberg J, Nyström B, Carter N, Edling C. Restless Legs syndrome among working-aged women. Eur Neurol 2001; 46(1): 17-9. ## [DOI:10.1159/000050750] [PMID]
3. Rutkove SB, Matheson JK, Logigian EL. Restless legs syndrome in patients with polyneuropathy. Muscle Nerve 1996; 19: 670-2. ## https://doi.org/10.1002/(SICI)1097-4598(199605)19:5<670::AID-MUS20>3.0.CO;2-Q [DOI:10.1002/(SICI)1097-4598(199605)19:53.0.CO;2-Q]
4. Ulfberg J, Nyström B, Carter N, Edling C. Prevalence of restless legs syndrome among men aged 18 to 64 years: an association with somatic disease and neuropsychiatric symptoms. Mov Disord 2001; 16(6): 1159-63. ## [DOI:10.1002/mds.1209] [PMID]
5. Phillips B, Young T, Finn L, Asher K, Hening WA, Purvis C. Epidemiology of restless legs symptoms in adults. Arch Intern Med 2000; 160(14): 2137-41. ## [DOI:10.1001/archinte.160.14.2137] [PMID]
6. Merlino G, Piani A, Dolso P. Sleep disorders in patients with end-stage renal disease undergoing dialysis therapy. Nephrol Dial Transplant 2006; 21: 184-90## [DOI:10.1093/ndt/gfi144] [PMID]
7. Batool-Anwar S, Li Y, De Vito K, Malhotra A, Winkelman J, Gao X. Lifestyle Factors and risk of restless legs syndrome: prospective cohort study. J Clin Sleep Med 2016; 12(2): 187-94. ## [DOI:10.5664/jcsm.5482] [PMID] []
8. Skomro RP, Ludwig S, Salamon E, Kryger MH. Sleep complaints and restless legs syndrome in adult type 2 diabetics. Sleep Med 2001; 2: 417-22. ## [DOI:10.1016/S1389-9457(01)00110-1] [PMID]
9. Sabic A, Sinanovic O, Sabic D, Galic G. Restless legs syndrome in patients with hypertension and diabetes mellitus. Med Arch 2016; 70(2): 116-8. ## [DOI:10.5455/medarh.2016.70.116-118] [PMID] []
10. sabzi Z, zahedi M, faroughi F. Methods of Controlling Restless Legs Syndrome in Diabetic Patients: A Scoping Review Study. Iranian Journal of Systematic Review in Medical Sciences(IJSR) Original Article 2024; 2(1) :11-18##
11. Kalra S, Gupta A. Diabetic Painful Neuropathy and Restless Legs Syndrome in Diabetes. Diabetes Ther 2018; 9: 441-7. ## [DOI:10.1007/s13300-018-0376-6] [PMID] []
12. Akın S, Bölük C, Türk Börü Ü, Taşdemir M, Gezer T, Şahbaz FG, et al. Restless legs syndrome in type 2 diabetes mellitus. Prim Care Diabetes 2019; 13: 87-91. ## [DOI:10.1016/j.pcd.2018.08.006] [PMID]
13. Bener A, Al-Hamaq AOAA, Ağan AF, Öztürk M, Ömer A. The prevalence of restless legs syndrome and comorbid condition among patient with type 2 diabetic mellitus visiting primary healthcare. J Family Med Prim Care 2019; 8(12): 3814-20. ## [DOI:10.4103/jfmpc.jfmpc_463_19] [PMID] []
14. Bosco D, Plastino M, Fava A, Ettore M, Bosco F, Ermio C, Tallarigo F, Pirritano D, Consoli D. Role of the Oral Glucose Tolerance Test (OGTT) in the idiopathic restless legs syndrome. J Neurol Sci 2009; 287(1-2): 60-3. ## [DOI:10.1016/j.jns.2009.09.008] [PMID]
15. Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Agúndez JAG. Association between restless legs syndrome and peripheral neuropathy: A systematic review and meta-analysis. Eur J Neurol 2021; 28(7): 2423-42. ## [DOI:10.1111/ene.14840] [PMID]
16. Walker S, Fine A, Kryger MH. Sleep complaints are common in a dialysis unit. American Journal of Kidney Diseases 1995; 26(5): 751-6. ## [DOI:10.1016/0272-6386(95)90438-7] [PMID]
17. Suzuki K, Ohida T, Sone T, Takemura S, Yokoyama E, Miyake T, Harano S, Motojima S, Suga M, Ibuka E. The prevalence of restless legs syndrome among pregnant women in Japan and the relationship between restless legs syndrome and sleep problems. Sleep 2003; 26(6): 673-7. ## [DOI:10.1093/sleep/26.6.673] [PMID]
18. Hening W, Walters AS, Allen RP, Montplaisir J, Myers A, Ferini-Strambi L. Impact, diagnosis and treatment of restless legs syndrome(RLS) in a primary care population: the REST (RLS epidemiology, symptoms, and treatment) primary care study. Sleep Med 2004; 5(3): 237-46. ## [DOI:10.1016/S1389-9457(04)00062-0] [PMID]
19. Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J. Restless Legs syndrome diagnosis and epidemiology workshop at the national institutes of health; international restless legs syndrome study group. restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the national institutes of health. Sleep Med 2003; 4(2): 101-19. ## [DOI:10.1016/S1389-9457(03)00010-8] [PMID]
20. Bjorvatn B, Leissner L, Ulfberg J, Gyring J, Karlsborg M, Regeur L, Skeidsvoll H, Nordhus IH, Pallesen S. Prevalence, severity and risk factors of restless legs syndrome in the general adult population in two Scandinavian countries. Sleep Med 2005; 6(4): 307-12. ## [DOI:10.1016/j.sleep.2005.03.008] [PMID]
21. Cuellar NG, Dorn JM. Peripheral diabetic neuropathy or restless legs syndrome in persons with type 2 diabetes mellitus: Differentiating diagnosis in practice. J Am Assoc Nurse Pract 2015; 27: 671-5. ## [DOI:10.1002/2327-6924.12311] [PMID]
22. Pinheiro T, Thomas T, Devaraj U, Ramachandran P, Krishnaswamy UM. Prevalence of restless legs syndrome and quality of sleep in type 2 diabetics. J Diabetes Complications 2020 ; 34(12): 107727. ## [DOI:10.1016/j.jdiacomp.2020.107727] [PMID]
23. Ning P, Mu X, Yang X, Li T, Xu Y. Prevalence of restless legs syndrome in people with diabetes mellitus: A pooling analysis of observational studies. EClinicalMedicine 2022; 46: 101357. ## [DOI:10.1016/j.eclinm.2022.101357] [PMID] []
24. Modarresnia L, Golgiri F, Madani NH, Emami Z, Tanha K. Restless Legs syndrome in iranian people with type 2 diabetes mellitus: the role in quality of life and quality of sleep. J Clin Sleep Med 2018; 14(2): 223-8. ## [DOI:10.5664/jcsm.6938] [PMID] []
25. Surani S, Brito V, Surani A, Ghamande S. Effect of diabetes mellitus on sleep quality. World J Diabetes 2015; 6(6): 868-73. ## [DOI:10.4239/wjd.v6.i6.868] [PMID] []
26. Skomro RP, Ludwig S, Salamon E, Kryger MH. Sleep complaints and restless legs syndrome in adult type 2 diabetics. Sleep Med 2001; 2(5): 417-22. ## [DOI:10.1016/S1389-9457(01)00110-1] [PMID]
27. Guo S, Huang J, Jiang H, Han C, Li J, Xu X, et al. Restless legs syndrome: from pathophysiology to clinical diagnosis and management. Front Aging Neurosci 2017; 9: 171. ## [DOI:10.3389/fnagi.2017.00171] [PMID] []
28. Zobeiri M, Shokoohi A. Restless leg syndrome in diabetics compared with normal controls. Sleep Disord 2014; 2014: 871751. ## [DOI:10.1155/2014/871751] [PMID] []
29. Cho YW, Na GY, Lim JG, Kim SH, Kim HS, Earley CJ, Allen RP. Prevalence and clinical characteristics of restless legs syndrome in diabetic peripheral neuropathy: comparison with chronic osteoarthritis. Sleep Med 2013; 14(12): 1387-92## [DOI:10.1016/j.sleep.2013.09.013] [PMID]
30. Ghanei Gheshlagh R, Parizad N, Zahednezhad H, Sarokhani M, Sayehmiri K, Baghi V. Prevalence of Restless Leg Syndrome in Iran: A Systematic Review and Meta-analysis. J Sleep Sci 2016; 1(3): 131-8. ##
31. Lopes LA, Lins Cde M, Adeodato VG, Quental DP, de Bruin PF, Montenegro RM Jr, et al. Restless legs syndrome and quality of sleep in type 2 diabetes. Diabetes Care 2005; 28(11): 2633-6. ## [DOI:10.2337/diacare.28.11.2633] [PMID]
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Razmeh S, Sattar F, Ahmadi S, Movahedpour A, Taghavian L, Ganjian F. Restless Legs Syndrome and Quality of Sleep in Pre-diabetic Patients: A Cross Sectional Study. armaghanj 2024; 29 (3) :456-466
URL: http://armaghanj.yums.ac.ir/article-1-3577-en.html


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Volume 29, Issue 3 (4-2024) Back to browse issues page
ارمغان دانش Armaghane Danesh
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