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The Effects of Shisheh on the Hormonal Axis Hypothalamus - Pituitary - Thyroid function in adult male Wistar Rats
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R Ahmadi1   , N Amini 1, A Ghasemi2 , A Seif3 |
1- Department of Biology, Faculty of Basic Sciences, Hamedan Branch, Islamic Azad University, Hamedan, Iran
2- Endocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Department of Statistics, Bu-Ali Sina University, Hamedan, Iran. |
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Abstract: (4447 Views) |
| Background & aim: Studies show that amphetamines can influence the hypothalamic-pituitary-thyroid axis. The aim of this study was to investigate the effects of Shisheh (met-amphetamine) on serum levels of T3, T4 and TSH in male rats.
Methods: In this laboratory experimental study 25 male Wistar rats were randomly divided to control, saline receiving, 2mg/kg, 4mg/kg, and 6mg/kg of Shisheh receiving groups of 5 rats in each. The injection was carried out intraperitoneally once a week for 6 weeks. After serum collection, T3, T4 and TSH levels were measured using ELFA method and the data were statically analyzed using ANOVA.
Results: Serum level of T3 and T4 was not significantly changed in rats receiving 2mg/kg of Shisheh compared with control animals. Serum level of T3 and T4 was signifintly increased in animals receiving 4mg/kg and 6mg/kg dose of Shisheh compared with the control rats (P<0.05 , P<0.001, respectively). Serum TSH level was significantly increased in rats receiving 2mg/kg, 4mg/kg, and 6mg/kg of Shisheh compared with control animals (P<0.001).
Conclusion: Our results indicate that Shisheh injection can enhance thyroid gland activity via acting on pituitary-thyroid axis, resulting in increased serum T3, T4 and TSH. |
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| Keywords: Shisheh, T3, T4, TSH, Rat. |
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Full-Text [PDF 284 kb]
(5181 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2015/04/4 | Accepted: 2015/04/4 | Published: 2015/04/4
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