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ABSTRACT: Introduction & Objective: The main purpose of radiotherapy is exposing enough doses of radiation to tumor tissue and protecting the normal tissues around it. Tumor dose for each session in radiotherapy will be considered based on radiosensitivity of the tissues. The presence of viral diseases in tumoral area can affect the radiosensitivity of cells. This study aimed to evaluate the radiosensitivity of Hela cells infected with poliomyelitis virus irradiated by Co 60. Materials & Methods: In this study, the radiosensitivity of HeLa cells, with or without the viral infection, after gamma radiation of cobalt 60, was assessed. Results: Results of comparison of the radisensitivity of infected and uninfected cells indicates that after 2 Gy irradiation by Co 60, polio infection in low, moderate and high virus load, increases the cell death by 20-30%, 30-40% and 70-90% respectively. Conclusion : Radiosensitivity of tumoral cells increase when they are infected with viral agents. Results of this study showed that non cancer diseases should be considered when prescribing dose fraction in radiotherapy of cancers.

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Abstract Background & aim: With different methods for diagnosing H. pylori infections the aim of this study was to compare barium swallows radiographic findings and serological tests for diagnosis of Helicobacter pylori infection in dyspeptic patients. Methods: In this analytic cross-sectional study, 60 patients with documented gastric or duodenal ulcer, referring to Yasuj Shahid Mofateh Clinic No.2 were randomly selected. For all patients, Serologic testing determining the Helicobacter pylori infection was performed using specific IgG antibody titer. Afterward, barium swallow radiograph was performed on all patients. The results of the diagnostic procedure was evaluated by the indices of sensitivity, specificity, positive predictive value, negative predictive value, the percentage of false positives, the percentage of false negative and true accuracy with 95% confidence interval were analyzed. Results: From a total of 60 serological testing, 37 patients (61.6 %) had positive and 23 (39.4 percent) had negative results. Barium swallows radiography of 7 out of 60 patients (11.7 percent) was positive. Among patients with positive serology, 5 patients had positive and 2 patients had negative results. Barium swallows sensitivity and specificity of serological tests was estimated 13.5 and 91 percent respectively. Conclusion: According to the high specificity percent, barium swallow radiography method can be considered as a confirmatory method in the diagnosis of H. pylori infection. Key words: Helicobacter pylori, serology, barium swallow, specificity, sensitivity

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Abstract Background and aim: β-lactamase enzymes producing bacteria ESBL have spread widely throughout the world. The production of enzymes induces bacterial resistance to a wide range of antibiotics which is leading to the limitation of infection control and correct treatment. The aim of the present study was to investigate patterns of antibiotic susceptibility to antibiotics and the presence of β-lactamase genes SHV, TEM, CTX-M, in Klebsiella pneumoniae isolates from clinical specimens of intensive care. Methods: Susceptibility of isolated bacteria against 10 antibiotics was determined by agar disk diffusion method according to the CLSI guidelines. The strains (DDST) were examined for the presence of the spectrum β-lactamase enzymes. Using E-test, the minimum inhibitory concentration (MIC) of the antibiotic was determined to cefotaxime. Moreover, SHV, TEM, CTX-M genes were identified by, Multiplex PCR method, and some of them were sequenced. Results: The antibiotic resistance against 10 antibiotics was determined. The highest percentage of isolates was resistant to ampicillin (100%) and sensitivity to imipenem was 1.66%). In this study, the majority of strains produced ESBL (60%). TEM gene in 34.38% and all three genes (TEM and SHV and CTX) at 33.13% of isolates were observed. Conclusion: The present study showed that the K. pneumoniae producing ESBL in patients in ICU are common. Therefore, the use of procedures and policies for infection control in hospitals and especially ICU is necessary. Key words: Klebsiella pneumoniae, ESBL, Multiplex PCR, antibiotic sensitivity

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Background & aim: Gestational diabetes is defined as diagnosing impaired glucose tolerance for the first time during pregnancy. The purpose of the present study was to compare the effect of aerobic and resistance training on fasting blood sugar, insulin and insulin resistance in women with gestational diabetes.

Methods: A total of 34 women with gestational diabetes voluntarily participated in the present Semi- experimental interventional study, which were selected from the available sampling pool. The participants were randomly assigned into 3 groups. 12 participants (age 28/92 ± 3/60 years) participated in an aerobic training group (3 days/week, 30-45 min/day, 50-70%maximum heart rate), 11 participants (age 30/27 ± 4/14 years) participated in a resistance training group (3 days/week, 2-3 set of 15 repetition, 50-70%maximum heart rate and Rating of perceived exertion), and 11 participants (age 29/18 ± 4/23 years)  were in control group who did not participate in any exercise program during the study period. Blood samples were collected in the pre-test and post-test to assess the level of blood sugar and insulin. Statistical analysis of covariance was used to compare the groups. The data were analyzed by the SPSS software (ver.23. The significant level was considered p≤0.05.

Results: The results of the present study showed a significant difference in insulin plasma levels  (p = 0.031), insulin resistance index (p = 0.008) and insulin sensitivity among groups. T-test results indicated a significant reduction in fasting blood sugar of resistance group (p=0.12) but no increase was observed in the aerobic group. At the levels of insulin, insulin resistance and insulin sensitivity, no significant changes were observed in exercise group.

Conclusion: It was concluded that resistance training compared with aerobic training was more effective in reducing fasting glucose levels in women with gestational diabetes.

 fasting blood sugar, insulin, insulin resistance, insulin sensitivity, pregnancy

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Background & aim: The emotional schema model emphasizes on evaluation and interpretation of anxiety symptoms and emotion regulation strategies. The present study aimed to determine the effectiveness of Emotional Schema Therapy (EST) on anxiety sensitivity and emotion regulation strategies.
 
Methods: The present research was a semi-experimental study with a pretest-posttest control group. The statistical population of the present study was adolescent girls with social anxiety disorder who were studying in the high schools of Delfan, Iran, during the academic year 2016-2017. For this purpose, 32 students with clinical symptoms of social anxiety were selected with screening method and were randomly assigned to experimental and control groups. The Social Phobia Inventory (SPIN) with clinical interviews were used for screening, the Anxiety Sensitivity Index (ASI) and Emotion Regulation Questionnaire (ERQ) were used to collect data in two conditions (pretest and posttest). then, the experimental group participated in the main intervention process of emotional schema therapy, which was directed by a PhD student of psychology in 10 sessions of 90 minutes, while the control group received no treatment intervention.  Data were analyzed using SPSS software (ver 23) and multivariate analysis of covariance (MANCOVA). 
 
Results: The results showed that in the experimental group in the post-test phase compared with the control group, the mean scores of anxiety and emotional regulation suppression were significantly decreased (P <0.001) however, the mean scores of the emotion regulation Was significantly increased (P <0.001). (Use numbers and figures in the findings.
 
Conclusion: The study findings proposed that emotional schema therapy can be used as an effective intervention in order to reduce symptoms of social anxiety and improved emotion regulation strategies in the people with clinical symptoms of social anxiety.
 
 

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Background & aim: In recent years, the rate of antibiotic resistance has been increasing which has led to the limitation of ways to control hospital infections (especially surgical site infections) and accurate treatment options. Therefore, the aim of the present study was to determine and investigate the frequency of plasmid-dependent quinolone resistance genes in Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli isolated from surgical site infections.

Methods: The present cross-sectional descriptive study was conducted on 45 isolates of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli isolated from surgical site infections of patients hospitalized at Yasuj hospitals in 2018. After identifying the isolates, they were checked for resistance to quinolone drugs by diffusion method from agar disk. Then, quinolone resistant isolates were examined for the presence of qnrB, qnrA and qnrS genes using PCR method. The collected data were analyzed using descriptive statistical tests and SPSS version 25 software.

Results: The highest rate of antibiotic resistance to Ciprofloxacin was 75.7%, and the rate of resistance to Levofloxacin and Ofloxacin were 73.3 and 62.2 percent, respectively; 24 (70.6%) isolates had at least one qnr gene, among these 24 isolates, 7 (20.6%) isolates contained qnrB gene, 4 (11.8%) isolates contained qnrA gene and 13 (2. 38 percent) isolates carried the qnrS gene. The results of the present study indicated the high prevalence of quinolone resistance due to plasmid (70.7%) among all isolates resistant to quinolones.

Conclusion: The final results of the present study indicated that the level of resistance to quinolone antibiotics in gram-negative bacteria isolated from surgical site infections had a high and significant prevalence, hence the use of appropriate treatment methods and correct and rational prescription antibiotics by physicians are correspondingly significant in their control.