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Introduction & Objective: Cardiovascular diseases represent the number one of causes of death in the United States. In addition to traditional medical treatment, alternative pharmacotherapy ,such as the use of vitamins, has been studied or tried by patients suffering from cardiovascular diseases. Antioxidant vitamins are the most frequently used medications in this regard. The aim of this study was to investigate the effect of vitamin E or combination of vitamin E and vitamin C on blood cholesterol, triglycerid, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) of patients undergoing lovestatin treatment. Materials & Methods: In a clinical trial, 93 hyperlipidemic patients were chosen and assigned in one of three drug groups. Group one received lovastatin plus placebo tablets. Group two received lovastatin plus vitamin E (400 IU), and group three lovastatin plus vitamin E and vitamin C (1000 mg) per day. Blood cholesterol, triglycerid, LDL, and HDL were measured before and following 10 weeks of medication. Results: Following 10 weeks of drug use, blood cholesterol, triglycerid and LDL were less and HDL was higher than these parameters at the beginning of the study. Comparison of results between three groups showed that the stuided parameters were not different in group three compared with group two, except for LDL. Conclusion: Adding antioxidant vitamins, particularly vitamin E, to medications of hyperlipidemic patients might be beneficial to these patients.