Dr Elham Karami, Dr Ramin Shabani, Dr Farhad Rahmaninia, Dr Alireza Elmieh, Dr Mahdi Rezagholizadeh,
Volume 30, Issue 1 (1-2025)
Abstract
Abstract
Background: The purpose of this study was to investigate the effect of eight weeks of aerobic training with vitamin E and C supplementation on the plasma levels of matrix metalloproteinas2 and matrix metalloproteinas9 in patients with coronary artery disease.
Methods & Materials: 60 patients with CAD were selected to participate in this research. Subjects were randomly divided into four groups (n=15) (training + supplement, training, supplement, and control). The subjects received 1 gr of D-alpha tocopherol and 1 gr of ascorbic acid daily. The training program was eight weeks (3 sessions per week) with an intensity of 40 to 80% reserve heart rate for 45 minutes of aerobic activity with treadmills, stationary bike, and manual ergometer as a standard cardiac rehabilitation program. Then, 24 hours before the first training session and 24 hours after the last training session, anthropometric evaluations and blood samples were received from the subjects. The analysis was analyzed using analysis of covariance and paired t-test at a significant level of p<0.05.
Results: The results showed that the level of MMP-2 in the plasma of patients with CAD was significantly higher in the aerobic training group with vitamin E and C supplementation than in the aerobic training group (p=0.001). Also, the level of MMP-9 in the plasma of patients with CAD in the aerobic training group with vitamin E and C supplementation was significantly lower than the aerobic training group (p=0.001).
Conclusion: combined aerobic training and taking vitamin E and C supplements can affect the plasma levels of the mentioned indicators to a greater extent and cause them to improve, which shows the higher efficiency of training at the same time as the supplement.
