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Showing 2 results for Servatkhah

Mahsa Servatkhah, Reza Mahmoudi, Alimohamad Kamali, Maryam Tajale, Mehrzad Jafari Barmak, Mohsen Nikseresht,
Volume 19, Issue 11 (2-2015)
Abstract

Background and aim: Breast cancer is the most common cancer which is threatening the health of women worldwide. Recent studies have found that pomegranate seed oil extract, may have potential anti cancer effect(s). The purpose of this study was to investigate the effects of pomegranate seed oil on the proliferation of human breast cancer cell lines MCF-7 and MDA-MB468. Methods: MCF-7 and MDA-MB468 cell lines were provided and grown in the culture media of RPMI-1640 containing 10% fetal bovine serum with the proper antibiotic. The pomegranate seed oil was extracted using petroleum ether. Cells were treated with different concentrations of pomegranate seed oil (100-1500 µg/ml) and viability was evaluated by using MTT assay. All of the experiments were performed triplicate. Result: After a period of 24, 48, and 72 hrs, the IC50 in MCF-7 cell lines and MDA-MB468 cell lines were 1150,742,731µg/ml and 842,700,588 µg/ml, respectively. Conclusions: The results revealed that pomegranate seed oil has the cytotoxicity effect on the two mentioned cell lines. Moreover, at different times with different concentrations, it (time and concentration dependent) prevented the proliferation of breast cancer cells. Therefore, perhaps it takes as a nutritional factor in the prevention of breast cancer.
E Enanat , H Delaviz , R Mahmoudi , A Roozbehi , , M Jafari Barmak , پرستو راد, M Servatkhah , F Moreidikia ,
Volume 20, Issue 7 (10-2015)
Abstract

Background & aim: Arginine by regulating the biological activity of the brain plays an important role in reducing stress. Today's, stress is one of the century disease that created many problem.  This study conducted to determine the protective effect of arginine on nitric oxide levels in maternal fetal brain tissue under stress.

Methods: Twenty pregnant Wistar rats (200-250 gr) were randomly divided into four groups. With and without stress groups received arginine (200 mg/kg) intraperitoneal from 5 – 20 days of pregnancies. Control with and sham without stress received 2 ml of normal saline. The pregnant rats were anesthetized by ketamine (100 mg/kg) on the day 20 then the fetuses removed and weighed. Twenty five brain of fetal brain rat from each group were chosen for measuring of forebrain thickness and brain volume. Another 25 brain were chosen for measuring of nitric oxide. Data were analyzed by one way ANOVA.

Results: Nitric oxide Levels reduced in stress rats treated with arginine compared to control group (P<0.05). The mean thickness of forebrain and hippicampal formation decreased in stress rats versus unstressed, but was not significant. The mean weight decreased significantly in stress group compared to the unstressed group (P<0.05).

Conclusions: Arginine could protect the brain tissue and fetal weight by reducing the level of oxidative stress in the pregnant rats.



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