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Abstract Background & aim: Considering the fact that infertility causes infertility problems in the marital relationship so, this study was aimed to determine the effectiveness of short-term couples therapy self-regulation on marital intimacy of infertile. Methods: In this clinical trial study, 20 couples were selected for sampling then they randomly into two experimental and control groups and each group was assigned 10 couples. Marital Intimacy scale was used to collect the data. Experimental intervention (self-regulatory couple therapy) was conducted on the experimental group for 8 sessions in duration of 90 minute per week. One month after completion of the training program, both groups were post-tested. Repeated measure was used to analyze the data. Results: The results showed that infertile couples marital intimacy increased self treatment groups compared with the control group (p<0.001). Conclusion: Short-term couple's therapy self-regulation is effective for increasing marital intimacy. Key words: Self-regulation, Couple Therapy, Marital Intimacy, Infertility