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Background & aim: Diabetes mellitus is an endocrine disorder that causes metabolic disturbances in the metabolism of carbohydrates, lipids and proteins.In the present study, the effect of hydroalcoholic extract of Dandelion on blood glucose, LDL, HDL and total cholesterol in diabetic rats was examined.
Methods: In the present experimental study conducted in the winter of 2001, thirty adult male Wistar rats were randomly divided into control, diabetic and diabetic treated with hydroalcoholic extract of Dandelion (50, 100 and 200 mg/kg) groups. Diabetes was induced by streptozotocin. Injections were intraperitoneally (I.P). After thirty days, the blood glucose, total cholesterol, HDL, LDL was measured. Data were analyzed using one-way ANOVA and Tukey tests.
Results: In the treatment groups at doses of 200, 100, 50 mg / kg, the extract of clover leaves significantly decreased the amount of clogs(p <0.01). Also LDL. VLDL and total cholesterol levels were significantly decreased in the extract-treated groups compared to the diabetic control group  (p<0.01).
Conclusion: Hydroalcoholic extract of Mulberry leaves improves the undesirable changes in LDL and HDL cholesterol, which may be of interest in reducing cardiovascular complications due to diabetes mellitus, as high doses of triglycerides by unmanageable extract Significantly decreased, therefore the synthesis of VLDL should be expected to decrease.