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Showing 2 results for Etemadi
V Ebrahimzadeh Attari , Mr Ardalan , S Abedi Azar, J Etemadi , A Malik Mahdavi , A Madah ,
Volume 27, Issue 5 (8-2022)
Abstract
Background & aim: Considering that overweight and obesity in transplant patients are considered as a risk factor for the occurrence of metabolic disorders, heart diseases and reduced kidney function, therefore, the purpose of the present study was to determine and investigate the relationship between anthropometric indicators and kidney function. In addition, the serum levels of fibroblast growth factor-23 and matrix gamma carboxyglutamate protein were markers of cardiovascular disease risk in kidney transplant patients.
Methods: The present study was conducted as a cross-sectional study in 2016-2019. Ninety kidney transplant patients referred to Tabriz Imam Reza (AS) hospital clinic, between 18 and 70 years of age and had normal kidney function and were within 6-12 months after transplant, were selected. Weight, height, waist circumference, body mass index and ratio of waist circumference to height were measured. Serum levels of fibroblast growth factor-23 and dephosphorylated and non-carboxylated protein matrix gamma carboxyglutamate were measured and glomerular filtration rate was calculated as an index of kidney function. Collected data were analyzed using Kolmogorov-Smirnov, Pearson and Spearman statistical tests.
Results: The mean and standard deviation of the age of the subjects was 44.10±13.05 years and 59% of the patients were male. Mean ± standard deviation of weight, body mass index, waist circumference and ratio of waist circumference to height of the patients were 69.61±11.59 kg, 25.77±4.42 kg/m2, 94.07±15.48 cm and respectively. It was 0.58±0.11. The prevalence of overweight and obesity based on body mass index was 38% and 17%, respectively. The mean ± standard deviation of the glomerular filtration rate is 57.45±12.61 ml/min per 1.73 square meter and the serum level of fibroblast growth factor-23 is 73.63±20.9 units/ml and the median (25th percentile) and the 75th percentile) the dephosphorylated and non-carboxylated protein gamma carboxy glutamate matrix of serum was also (1.3, 60.20) 2.40 micrograms/liter. Significant correlation between anthropometric indices with glomerular filtration rate and serum levels of fibroblast growth factor-23 and matrix gamma carboxy glutamate dephosphorylated and non-carboxylated protein, as well as between glomerular filtration rate and serum levels of fibroblast growth factor-23 and matrix gamma carboxy glutamate dephosphorylated protein and Non-carboxylated was not observed (p>0.05). A significant inverse correlation was observed between serum levels of fibroblast growth factor-23 and dephosphorylated and non-carboxylated protein gamma-carboxyglutamate matrix (p=0.036).
Conclusion: Considering that in the present study, the average weight, body mass index and also the performance of all patients were almost within the normal range, therefore, there is a significant relationship between anthropometric indices with glomerular filtration rate and serum levels of fibroblast growth factor-23 and gamma carboxy matrix. Dephosphorylated and non-carboxylated protein glutamate was not observed.
M Etemadiyan , A Larki Harchgani , Mr Nooryan , M Soleimani Badie , R Mahjoub , M Mohammadi,
Volume 28, Issue 3 (4-2023)
Abstract
Background & aim: Considering the importance of the skin in regulating the temperature and maintaining body fluids and its prominent role in the defense system, it is important to improve any discontinuity in the skin, which is called a wound. Although limited and superficial wounds heal by themselves, the treatment of deep wounds requires drug therapy. Therefore, the aim of this study was to determine and prepare a topical cream containing the extract of the sumac plant (Rhus Coriaria L) and compare its effect with phenytoin in healing skin wounds in an animal model.
Methods: In the present study conducted in 2021-2022, twenty-five New Zealand laboratory rabbits, with the weight range of 2500-3000 grams, were obtained from central animal house, Hamadan University of Medical Sciences. The rabbits were randomly divided into five groups: I) Control Group; II) Receiving Phenytoein cream (1%) as the medical therapy; III) Receiving the placebo cream base; IV) Receiving therapeutic cream containing standardized sumac extract (0.1% of tannic acid); and V) Receiving therapeutic cream containing standardized sumac extract (0.05% of tannic acid). Then, a wound, with dimension of 2*2 cm, was induced in the back of any rabbits and the appropriate topical therapy was administered twice daily on the rabbits. The effectiveness of therapy using creams containing sumac extract was determined using the extent of wound healing and the level of hydroxyproline. The obtained data were statistically analyzed using One-way Analysis of Variance (ANOVA).
Results: It was demonstrated that each one gram of standardized extract contained 2.74±0.86 milligram of tannic acid. The data achieved from the study, including the determination of hydroxyl-proline levels, percentage of wound healing, and the duration of remission, demonstrated significant efficiency in treatment with sumac-containing creams (either 0.1% or 0.05%). Histological studies revealed more condensed collagen fibrils and more reduction of inflammation cells in treatment groups receiving sumac-containing cream (either 0.01% or 0.05%) compared with the control group.
Conclusion: Sumac-containing creams, due to anti-oxidative properties and enhancing synthesis of hydroxyl-proline, can condense collagen fibrils which consequently cause improved wound healing.
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