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Abstract
Background & aim: The anti-diabetic effects of Walnut green skin have attracted many researchers in the recent years.The aim of this study was to evaluate the effects of green skin extract on the serum level of sugar, lipid profile, and ALP, ALT, AST enzymes in adult male diabetic rats.
 
Methods: In the present experimental study, 32 adult male rats were divided into 4 groups of 8, including control, treated with medicine solvent, diabetic with 60 mg/kg dose of streptozotocin, and diabetic under 10 day treatment of 100 mg/kg dose of green skin extract of walnut groups. At the end, the serum level of glucose, triglyceride, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), Alkaline Phosphatase (ALP), Alanine aminotransferase (ALT), and Aspartate aminotransferase (AST) enzymes are measured. Data were analyzed by ANOVA and Tukey tests.
 
Results:The results of this study indicated that in diabetic animals,  in comparison with control group, serum levels of ALP, ALT, AST enzymes, glucose, triglyceride, and LDL were increased, and HDL level decreased (P = 0.001). While in diabetic rats treated with green skin extract,in comparison with diabetic animals, the level of serum ALP, ALT, AST enzymes, glucose, triglyceride, and LDL decreased and HDL increased compared to diabetic animals(P = 0.001).
Conclusion:The green skin extract of walnut with anti-diabetic effects reduces glucose, liver transaminases, and lipid profiles in diabetic animals