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:: Volume 30, Issue 3 (4-2025) ::
__Armaghane Danesh__ 2025, 30(3): 374-387 Back to browse issues page
Longitudinal Changes in BMI Among Adult Undergoing Allogenic Hematopoietic Stem Cell Transplantation: Evidence from Shariati Hospital, Tehran
S Mahmoudi1 , M Barkhordar2 , R Amiri Khosrowshahi1 , H Imani1 , M Vaezi3 , SB Panahandeh4 , H Mohammadi5
1- Department of Clinical Nutrition, Tehran University of Medical Sciences, Tehran, Iran
2- Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
3- Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
4- Department of Nutrition, Yasuj University of Medical Sciences, Yasuj, Iran
5- Department of Clinical Nutrition, Tehran University of Medical Sciences, Tehran, Iran , mohamadihd@gmail.com
Abstract:   (871 Views)
Background & aim:  Hematopoietic stem cell transplantation (HSCT) is known as an effective treatment for neoplastic and non-malignant blood diseases. This treatment method is associated with many metabolic and nutritional challenges, one of the most important of which is malnutrition and changes in body mass index (BMI). Therefore, the aim of the present study was to determine and change body mass index in adult patients who are candidates for allogeneic hematopoietic stem cell transplantation.


Methods: This prospective, longitudinal, single-center study was conducted on 195 patients who were candidates for allogeneic hematopoietic stem cell transplantation at Shariati Hospital in Tehran. BMI measurements were taken at three different time points: before transplantation, one month after transplantation, and 100 days after transplantation. The collected data were analyzed using the Kolmogorov-Smirnov test, repeated-measures analysis of variance, and Greenhouse-Geisser correction.

Results: Of the 195 patients studied, 125 were male (64%) and 70 were female (36%). In this study, the most common primary diagnosis was acute myeloid leukemia (AML) with a prevalence of 50.8%, followed by acute lymphoblastic leukemia (ALL) with a prevalence of 33.8%. Other diagnoses including myelodysplastic syndrome (MDS), myelofibrosis (MF), paroxysmal nocturnal hemoglobinuria (PNH), aplastic anemia (AA), and Hodgkin's disease (HD) accounted for a total of 15.5% of cases. The mean BMI of the patients decreased significantly over time (p<0.001). Among the clinical variables, graft-versus-host disease (GVHD), length of hospital stay, and primary diagnosis were significantly associated with BMI changes (p<0.001).

Conclusion: The findings of the present study indicated that changes in BMI are common during allogeneic hematopoietic stem cell transplantation and are affected by different clinical factors like the severity of GVHD, Length of hospitalization, and their initial diagnosis. Accurate monitoring of patients’ nutritional status and appropriate interventions during and after treatment may play an important role in improving clinical outcomes for these patients.

 
Keywords: Body Mass Index, Malnutrition, Allogeneic Hematopoietic Stem Cell Transplantation.
Full-Text [PDF 429 kb]   (23 Downloads)    
Type of Study: Research | Subject: Nutrition
Received: 2025/05/6 | Accepted: 2025/09/14 | Published: 2025/09/20
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Mahmoudi S, Barkhordar M, Amiri Khosrowshahi R, Imani H, Vaezi M, Panahandeh S et al . Longitudinal Changes in BMI Among Adult Undergoing Allogenic Hematopoietic Stem Cell Transplantation: Evidence from Shariati Hospital, Tehran. armaghanj 2025; 30 (3) :374-387
URL: http://armaghanj.yums.ac.ir/article-1-3799-en.html


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Volume 30, Issue 3 (4-2025) Back to browse issues page
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